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Plasma exchange with plasma protein fraction and lactated Ringer's solution using the continuous flow cell separator
Infusionstherapie Und Klinische Ernahrung
|August 1, 1975
Summary
Plasma exchanges using Plasma Protein Fraction (PPF) and Lactated Ringer's Solution (LRS) are safe and effective. This method maintained adequate coagulation factor activity, preventing complications in patients undergoing the procedure.
Area of Science:
- Hematology
- Medical Technology
- Clinical Trials
Background:
- Plasma exchange is a critical procedure for various medical conditions.
- Traditional plasma exchange often utilizes fresh frozen, modified, or lyophilized plasma.
- Alternative, readily available plasma components may offer advantages in plasma exchange therapy.
Purpose of the Study:
- To evaluate the safety and efficacy of using Plasma Protein Fraction (PPF) and Lactated Ringer's Solution (LRS) in plasma exchange.
- To assess the impact of this alternative exchange material on coagulation factor activity.
- To determine the clinical outcomes and complications associated with this modified plasma exchange protocol.
Main Methods:
- Ten patients underwent plasma exchange procedures.
- Continuous flow cell separation was employed for the exchanges.
- The exchange fluid comprised Plasma Protein Fraction (PPF) and Lactated Ringer's Solution (LRS).
Main Results:
- No bleeding or other procedural complications were observed in any patient.
- Coagulation factor activity remained above the hemostatic threshold post-exchange.
- The procedure was completed without adverse events.
Conclusions:
- Plasma exchange using PPF and LRS is a safe and viable alternative to traditional plasma.
- This method effectively maintains hemostatic levels of coagulation factors.
- The procedure is efficient and well-tolerated by patients.