Norplant-2 subdermal contraceptive system: experience in Taiwan

Area of Science:

• Reproductive Health
• Contraception
• Endocrinology

Background:

• Subdermal implants offer sustained drug release for long-term contraception.
• Norplant-2 utilizes levonorgestrel for reversible birth control.
• Global use of levonorgestrel implants is established.

Purpose of the Study:

• To evaluate the efficacy and safety of Norplant-2 in Taiwan.
• To assess continuation rates and reasons for discontinuation.
• To investigate metabolic and hematological effects of Norplant-2.

Main Methods:

• Prospective study of 267 female volunteers at National Taiwan University Hospital.
• 36-month follow-up of Norplant-2 subdermal implants.
• Monitoring of pregnancy rates, continuation rates, adverse events, and biochemical parameters.

Main Results:

• Pregnancy rate of 0.4% (1/231) after 36 months.
• Continuation rates: 84.5% (12 mo), 61.3% (24 mo), 52.0% (36 mo).
• Menstrual problems were primary cause for discontinuation; fertility returned rapidly post-removal. Decreased cholesterol/triglycerides, increased hemoglobin; no liver/renal toxicity.

Conclusions:

• Norplant-2 is a highly effective, safe, and long-acting reversible contraceptive.
• Menstrual irregularities are the main concern but do not negate overall safety.
• Introduction into Taiwan's family planning program is recommended.