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Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?
1Medical and Clinical Pharmacology Laboratory, Faculty of Medicine, Marseille, France.
The Journal of Pharmacy and Pharmacology
|July 1, 1993
Abstract:
We have investigated the possible influence of time of day on the activity of flumazenil on lignocaine-induced toxicity in mice. The circadian pattern of the period of latency for convulsions and the induced mortality for lignocaine alone and for lignocaine plus flumazenil was not statistically significant (cosinor or analysis of variance) but the influence of flumazenil on lignocaine-induced toxicity was circadian-time dependent (F = 27.8, P = 0.0001).