Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A survey on quantitative microdialysis: theoretical models and practical implications

J Kehr1

  • 1CMA/Microdialysis AB, Stockholm, Sweden.

Journal of Neuroscience Methods
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.

Molecular psychiatry·2012
Same author

Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®.

International psychogeriatrics·2012
Same author

Determination of histamine in microdialysis samples from Guinea pig skin by high-performance liquid chromatography with fluorescence detection.

Skin pharmacology and physiology·2011
Same author

Galanin differentially regulates acetylcholine release in ventral and dorsal hippocampus: a microdialysis study in awake rat.

Neuroscience·2011
Same author

Impaired social interaction and enhanced sensitivity to phencyclidine-induced deficits in novel object recognition in rats with cortical cholinergic denervation.

Neuroscience·2011
Same author

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats.

British journal of pharmacology·2011
Same journal

Pupil-DLC: an open-source deep learning pipeline for scalable, marker-less tracking of pupil dynamics across conscious and unconscious states.

Journal of neuroscience methods·2026
Same journal

Time as the language of Behavior: events, sequences, patterns and meanings.

Journal of neuroscience methods·2026
Same journal

Detection of cochlear microphonic for differential diagnosis between auditory neuropathy mice and noise-induced sensorineural hearing loss mice.

Journal of neuroscience methods·2026
Same journal

Assessment metrics for pain control in rats: A methodological commentary.

Journal of neuroscience methods·2026
Same journal

Infant EEG preprocessing pipelines: A capability framework and current gaps in practice.

Journal of neuroscience methods·2026
Same journal

Methods for measuring neural activity during voluntary wheel running.

Journal of neuroscience methods·2026
See all related articles

Quantitative microdialysis methods are reviewed, highlighting their historical development and limitations. Empirical models and reference substance methods offer practical solutions for accurate brain extracellular space analysis.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biomedical Engineering

Background:

  • Quantitative microdialysis is crucial for studying brain extracellular space.
  • Existing methods vary in mathematical models and theoretical principles.
  • Historical perspective reveals evolution and limitations of these techniques.

Purpose of the Study:

  • To review and categorize existing quantitative microdialysis methods.
  • To analyze the contributions, limitations, and drawbacks of each method.
  • To emphasize the importance of quantitative evaluation in microdialysis.

Main Methods:

  • Classification of methods into 8 groups based on mathematical models.
  • Historical analysis of each method's development and application.

Related Experiment Videos

  • Discussion of empirical models and reference substance techniques.

    • Main Results:

    • Methods relying on derived in vivo recovery equations are often too approximate for routine use.
    • Empirical models using varying perfusion parameters show practical utility.
    • Reference substance methods provide a marker for in vivo recovery.

    Conclusions:

    • Quantitative microdialysis is essential for measuring neurotransmitters, drug concentrations, and pharmacokinetic variables.
    • Empirical and reference substance methods offer more practical quantitative evaluation.
    • Further development is needed for universally applicable quantitative microdialysis techniques.