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Pemphigus foliaceus induced by nifedipine
1Department of Dermatology, Yonsei University Wonju College of Medicine, Korea.
Acta Dermato-Venereologica
|June 1, 1993
Summary
Nifedipine can cause pemphigus foliaceus, a rare autoimmune skin condition. This case study confirms nifedipine as the cause, with symptoms resolving after drug withdrawal and steroid treatment.
Area of Science:
- Dermatology
- Pharmacology
- Autoimmunology
Background:
- Pemphigus foliaceus is a rare autoimmune blistering disease affecting the skin.
- Drug-induced pemphigus is an uncommon but significant adverse reaction to certain medications.
Observation:
- A patient developed pemphigus foliaceus with characteristic skin lesions.
- Nifedipine, a calcium channel blocker, was identified as the potential causative agent.
Findings:
- Rechallenge with nifedipine confirmed it as the direct cause of the pemphigus foliaceus.
- Discontinuation of nifedipine led to rapid improvement of skin lesions.
Implications:
- This case highlights nifedipine as a potential trigger for drug-induced pemphigus foliaceus.
- Early identification and withdrawal of the offending drug are crucial for managing nifedipine-induced pemphigus.
- Clinicians should consider nifedipine in the differential diagnosis of new-onset pemphigus foliaceus.