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Oncogene elements within an endogenous retrovirus
K A Whartenby1, R A Insel, S M Freeman
1Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642.
Abstract:
The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.