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C-erbB-2/HER-2 protein in human intracranial tumours
S H Torp1, E Helseth, G Unsgaard
1Institute of Cancer Research, University of Trondheim, Norway.
European Journal of Cancer (Oxford, England : 1990)
|January 1, 1993
Abstract:
Normal and neoplastic human intracranial tissues were examined by immunohistochemistry for c-erbB-2/HER-2 protein expression. Positive staining was observed in 1/41 gliomas, 1/2 medulloblastomas, 1/1 germinoma, 11/16 meningiomas, 1/3 anaplastic meningiomas and 11/19 metastatic brain carcinomas. No positive staining was observed in normal intracranial tissues. Thus, the expression of the c-erbB-2/HER-2 protein is limited to intracranial tumour tissues, principally meningiomas and metastatic carcinomas to the brain.