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Related Experiment Videos

Immunosuppression in sclerosing peritonitis

B J Junor1, M A McMillan

  • 1Renal Unit, Western Infirmary, Glasgow, United Kingdom.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1993
PubMed
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Sclerosing peritonitis (ScP), a complication of continuous ambulatory peritoneal dialysis (CAPD), can be fatal. Immunosuppressive therapy, with or without a renal transplant, significantly improved patient survival in this study.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Immunology

Background:

  • Sclerosing peritonitis (ScP) is a rare, fatal complication of continuous ambulatory peritoneal dialysis (CAPD), often presenting as small bowel obstruction.
  • Historically, renal transplant was the only observed factor associated with prolonged survival post-ScP diagnosis.

Purpose of the Study:

  • To investigate the efficacy of immunosuppressive therapy in improving survival rates for patients diagnosed with sclerosing peritonitis (ScP).

Main Methods:

  • Retrospective analysis of 17 patients diagnosed with ScP via laparotomy.
  • Observation of patient outcomes based on treatment: discontinuation of CAPD, immunosuppressive therapy, and renal transplantation.
  • Correlation of chlorhexidine-alcohol exposure with ScP incidence.

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Main Results:

  • 12 out of 17 patients died within a year from recurrent bowel obstruction; none received immunosuppressive therapy.
  • The remaining 5 patients received immunosuppressive therapy, with 4 surviving between 1 and 9 years.
  • One patient, initially immunosuppressed without a transplant, remained well for 18 months, suggesting immunosuppression's benefit.

Conclusions:

  • Immunosuppressive therapy appears to be a beneficial treatment for sclerosing peritonitis (ScP).
  • Prolonged survival in ScP patients can be achieved with immunosuppression, independent of renal transplant status.
  • Further research into the role of immunosuppression in managing ScP is warranted.