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Related Experiment Videos

Choroid plexus papilloma in an infant

K Kunishio1, S Kawada, T Matsuhisa

  • 1Department of Neurosurgery, Kagawa Prefectural Central Hospital.

Noshuyo Byori = Brain Tumor Pathology
|January 1, 1993
PubMed
Summary

This study reports a rare case of choroid plexus papilloma in an infant that overproduced cerebrospinal fluid. Complete surgical resection led to normal growth without the need for shunting, indicating a favorable outcome for this pediatric brain tumor.

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Area of Science:

  • Pediatric Neurosurgery
  • Neuro-oncology
  • Cerebrospinal Fluid Dynamics

Background:

  • Choroid plexus papillomas (CPPs) are rare tumors in infants, often associated with cerebrospinal fluid (CSF) overproduction.
  • Hydrocephalus due to CSF hypersecretion is a common complication of pediatric CPPs.

Observation:

  • A case of infant choroid plexus papilloma (CPP) presenting with significant CSF overproduction is detailed.
  • The tumor exhibited histological features of CPP with mitotic activity but lacked definitive malignant indicators.
  • Transthyretin immunoreactivity was confirmed in tumor cells via CSF cytology and surgical specimens.

Findings:

  • Complete surgical resection of the CPP was achieved.
  • High PCNA (proliferating cell nuclear antigen) percentage (10.8%) was noted, but not exceeding levels seen in benign CPPs.

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  • Post-operative follow-up with CT and MRI at 1 year showed no recurrence or dissemination.

    • Implications:

    • Total resection of pediatric choroid plexus papilloma can lead to favorable outcomes, including normal development without CSF shunting.
    • This case highlights the importance of accurate histological and immunohistochemical evaluation for managing pediatric brain tumors.
    • Early and complete surgical intervention is crucial for preventing long-term complications associated with hydrocephalus in infants with CPP.