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Nephrotic syndrome in the elderly--clinicopathological study
Y Ozono1, T Harada, K Yamaguchi
12nd Department of Internal Medicine of Nagasaki University, Japan.
Nihon Jinzo Gakkai Shi
|January 1, 1994
Summary
Nephrotic syndrome in elderly patients often involves membranous nephropathy. Treatment effectiveness varied, with significant side effects observed, particularly in secondary nephrotic syndrome cases.
Area of Science:
- Nephrology
- Geriatrics
- Pathology
Background:
- Nephrotic syndrome (NS) in patients over 60 presents unique challenges.
- Understanding primary and secondary causes is crucial for effective management.
Purpose of the Study:
- To investigate clinical and pathological findings in elderly NS patients.
- To evaluate the effects of therapy and identify common causes and side effects.
Main Methods:
- Retrospective analysis of 90 elderly NS patients.
- Review of clinical data, pathological findings, and treatment outcomes.
Main Results:
- Membranous nephropathy was the most common primary NS.
- Amyloidosis and malignancy were frequent causes of secondary NS.
- Prednisolone and immunosuppressants were effective for membranous NS; prednisolone alone for minimal change NS.
Conclusions:
- Elderly NS requires tailored treatment strategies.
- Secondary NS, especially due to malignancy, has a poor prognosis.
- Infections are significant side effects of therapy in this population.