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Effect of hyperlipemia on pulmonary diffusing capacity at rest and during exercise
K M Kratina1, C W Zauner, R A Siders
1Department of Exercise and Sports Sciences, University of Florida, Gainesville.
The Journal of Sports Medicine and Physical Fitness
|September 1, 1993
Summary
Alimentary hyperlipemia, or high blood fat from meals, did not significantly impact pulmonary diffusing capacity for carbon monoxide (DLco) during rest or exercise in men. This study investigated the effects of dietary fat on lung function during physical activity.
Area of Science:
- Physiology
- Pulmonary Medicine
- Metabolic Studies
Background:
- Existing data suggest impaired pulmonary gas exchange during hyperlipemia.
- The impact of alimentary hyperlipemia on lung function requires further investigation.
Purpose of the Study:
- To investigate the effect of alimentary hyperlipemia on steady-state pulmonary diffusing capacity for carbon monoxide (DLco) at rest and during exercise.
- To determine if increased serum lipids alter lung diffusing capacity.
Main Methods:
- Twelve healthy men underwent DLco measurements after fasting and after ingesting a high-fat meal.
- DLco was assessed at rest, during 49-watt cycling, and at a heart rate of 150 bpm.
- Serum optical density was measured to quantify lipemia, with data analyzed using ANOVA.
Main Results:
- Alimentary hyperlipemia was successfully induced, as evidenced by a significant increase in serum optical density (p < 0.05).
- Mean DLco values were numerically lower after fat ingestion at both exercise intensities (49W and 150 bpm).
- Despite a trend towards lower DLco, the changes were not statistically significant.
Conclusions:
- Alimentary hyperlipemia does not significantly impair pulmonary diffusing capacity for carbon monoxide at rest or during moderate exercise.
- Further research may be needed to explore potential subtle effects or different exercise conditions.