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Peripheral blood hairy cell leukemia cells express only low affinity IL-2 receptors
K Bulger1, J Murphy, A Janckila
1Section of Medical Oncology, Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118.
Leukemia Research
|February 1, 1994
Abstract:
Purified leukemia cells from three patients with hairy cell leukemia were studied for IL-2 receptor status. All samples expressed the p55IL-2 receptor subunit. However, none demonstrated sensitivity to the IL-2-diphtheria toxin conjugate, DAB486IL-2, which shows selective cytotoxicity for high affinity IL-2 receptor-bearing cells. In the one case studied with 125I-IL-2 binding, only low affinity IL-2 receptors were noted. These data suggest that hairy cell leukemia cells express only low affinity IL-2 receptors and are insensitive to DAB486IL-2.