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Thermal denaturation of B. subtilis DNA in H2O and D2O observed by electron microscopy
Nucleic Acids Research
|October 1, 1975
Abstract:
In the present work we studied the initial part of thermal denaturation curves of B. subtilis DNA in normal and heavy water, observing, by electron microscopy, the "opening" of DNA as a function of temperature. The results support the hypothesis that D(2)O plays a stabilizing role on strands separation during thermal denaturation of DNA.