Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid

To evaluate and compare the efficacy and adverse effects of trichloracetic acid and cryotherapy (using liquid nitrogen) in the treatment of external genital warts.

Eighty-six patients were enrolled into a randomized clinical trial in the Genitourinary Medicine Department of the Coventry and Warwickshire Hospital (Coventry) between November 1990 and June 1991. External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis. They received up to six treatments of either therapy.

Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid. Thirty percent of patients who were treated with trichloracetic acid developed ulcerations at the site of its application.

In this study we found that cryotherapy (using liquid nitrogen) is more effective than that of trichloracetic acid for the treatment of external genital warts. It is also less likely to cause ulceration.