Related Experiment Video

Updated: Aug 27, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Plasma renin activity in oedematous and marasmic children with protein energy malnutrition

J M van der Westhuysen, E Kanengoni, J J Jones

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |October 4, 1975
    PubMed

    Insights

    Plasma renin activity was significantly elevated in children suffering from kwashiorkor and marasmus, indicating a potential link to cardiovascular changes in severe malnutrition. This finding is crucial for understanding the physiological responses to malnutrition.

    Area of Science:

    • Pediatric Nutrition
    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • Kwashiorkor and marasmus are severe forms of malnutrition.
    • Renin-angiotensin-aldosterone system plays a role in cardiovascular regulation.
    • Understanding physiological changes in malnutrition is critical.

    Purpose of the Study:

    • To measure plasma renin activity in children with kwashiorkor and marasmus.
    • To compare renin activity between malnourished children and healthy controls.
    • To investigate the relationship between renin activity and clinical outcomes.

    Main Methods:

    • Bio-assay was used to measure plasma renin activity.
    • Study included 52 children with kwashiorkor, 28 with marasmus, and 21 healthy children.
    • Comparison of plasma renin activity between groups and outcomes.

    Main Results:

    • Plasma renin activity was significantly increased in children with kwashiorkor and marasmus compared to healthy children.
    • Elevated renin activity was observed in non-survivors compared to survivors.
    • No direct correlation was found between renin activity and edema severity in kwashiorkor.

    Conclusions:

    • Increased plasma renin activity is associated with severe malnutrition (kwashiorkor and marasmus).
    • Elevated renin activity may reflect terminal cardiovascular dysfunction in malnourished children.
    • Further research is needed to elucidate the precise role of renin in malnutrition.

    More Related Videos

    Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin07:38

    Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

    Published on: May 6, 2018

    A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

    A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

    Published on: October 26, 2020

    Related Concept Videos

    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

    Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
    Nephrotic Syndrome II : Assessment and Medical Management01:26

    Nephrotic Syndrome II : Assessment and Medical Management

    IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
    Serum Studies: Renal Function Tests01:24

    Serum Studies: Renal Function Tests

    Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
    Acute Kidney Injury V: Interprofessional Care01:20

    Acute Kidney Injury V: Interprofessional Care

    Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...