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Decreased myocardial fibrinolytic activity following temporary ischaemia and reperfusion
Thrombosis Et Diathesis Haemorrhagica
|September 30, 1975
Abstract:
The effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and 125I fibrinogen incorporation into fibrin was investigated in nine baboons. Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the 125I fibrinogen activity was elevated by 480%. The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.