Neurotransplantation: a clinical update

The use of grafts to correct neurological disorders has great promise. The progress toward this goal, as it relates to Parkinson's disease, is briefly reviewed. Although there are a number of questions that remain unanswered, recent reports of improvement in parkinsonian symptoms are very encouraging. In order to successfully evaluate the clinical trials, multicenter and/or standardized reporting techniques will be required. Future studies will need to concentrate on improving the graft survival and ability of the graft to reinnervate the host. Eventually alternative tissues may alleviate the need for fetal tissue. The use of neurotrophic factors should prove an important adjuvant to the repair and restoration of lost neurological function. As this technology is applied to other neurological diseases, it will be important to evaluate the appropriateness of grafting through extensive animal model studies and to balance the potential benefits of such therapy against the degree of risk from surgery and the severity of the disease.