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[The effects of various doses of lipopolysaccharide on endotoxin-induced uveitis in rats]
M Ishiguro1, T Katayama, K Tachinami
1Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Abstract:
We induced intraocular inflammation by foot pad injection of lipopolysaccharide (LPS) in rats to investigate the inflammatory effects of the various doses of the LPS and the anti-inflammatory effects of prostaglandin (PG) synthetase inhibitor. The aqueous protein concentration curve showed two peaks, an early one at 3 hours and another at 24 hours after the injection, at doses higher than 12.5 micrograms per rat. The PG synthetase inhibitor reduced the aqueous protein concentration by 30 to 60% at both of the two peaks. These results suggest the involvement of PG in the mechanism of the endotoxin-induced uveitis.