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Related Experiment Videos

Psychologic symptoms before and after parathyroid surgery

B L Solomon1, M Schaaf, R C Smallridge

  • 1Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, D.C. 20307-5001.

The American Journal of Medicine
|February 1, 1994
PubMed
Summary

Patients with primary hyperparathyroidism experience significant psychological distress, including depression and anxiety, which substantially improves one month after parathyroidectomy surgery. This study highlights the impact of hyperparathyroidism on mental well-being.

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism is associated with various symptoms, but its impact on psychological well-being requires further investigation.
  • Understanding the psychological burden in primary hyperparathyroidism is crucial for comprehensive patient care.

Purpose of the Study:

  • To assess the type and severity of psychological symptoms in patients with primary hyperparathyroidism before and after parathyroidectomy.
  • To evaluate the effectiveness of parathyroidectomy in alleviating psychological distress.

Main Methods:

  • A cohort of 18 patients with primary hyperparathyroidism and 20 controls with benign thyroid disease were studied.
  • Psychological symptoms were assessed using the Symptom Checklist-90-Revised (SCL-90-R) preoperatively and at 1, 3, and 6 months postoperatively.

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  • Serum calcium, parathyroid hormone, and other biochemical markers were monitored.

    • Main Results:

    • Hyperparathyroid patients exhibited higher preoperative levels of serum calcium and parathyroid hormone, normalizing within one month post-surgery.
    • Preoperative psychological distress was multidimensional, affecting obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, and psychoticism.
    • Significant symptom improvement was observed by one month after parathyroidectomy, with scores approaching normative values.

    Conclusions:

    • Parathyroidectomy leads to profound improvement in psychological symptoms within one month.
    • The Symptom Checklist-90-Revised is an effective tool for quantifying psychological distress in primary hyperparathyroidism.
    • Somatization and anxiety symptoms did not significantly differ between hyperparathyroid patients and controls.