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On genetic and environmental factors in Menière's disease

A W Morrison1, J F Mowbray, R Williamson

  • 1Royal London Hospital, London, England.

The American Journal of Otology
|January 1, 1994
PubMed

Insights

Menière

Area of Science:

  • Genetics
  • Immunology
  • Otolaryngology

Background:

  • The exact cause of Menière's disease (MD) is unknown.
  • Previous research linked sporadic MD to human leukocyte antigen (HLA) genotypes and disease activity to enterovirus (VP1).

Purpose of the Study:

  • To investigate familial Menière's disease (MD) and its genetic links.
  • To explore the association between HLA genotypes, chromosome 6, and MD.
  • To confirm the link between viral protein 1 (VP1) and MD activity.

Main Methods:

  • Studied families with multiple Menière's disease (MD) patients.
  • Analyzed human leukocyte antigen (HLA) associations on chromosome 6.
  • Measured enterovirus viral protein 1 (VP1) in familial MD patients and correlated with disease activity.

Main Results:

  • Confirmed association between Menière's disease (MD) and HLA class I haplotypes in both sporadic and familial cases.
  • Identified a potential MD locus between HLA-C and HLA-A on chromosome 6.
  • Reaffirmed the link between circulating VP1 and Menière's disease (MD) activity.

Conclusions:

  • Familial Menière's disease (MD) predisposition may be due to a mutation (M1) on chromosome 6.
  • The findings support a genetic component on chromosome 6 for Menière's disease (MD).
  • Enterovirus protein 1 (VP1) detection correlates with Menière's disease (MD) activity.

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