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Related Experiment Videos

Posturally induced vasoconstriction in diabetes mellitus

A C Shore1, K J Price, D D Sandeman

  • 1Diabetes Research Laboratory, Postgraduate Medical School, University of Exeter.

Archives of Disease in Childhood
|January 1, 1994
PubMed
Summary

Standing normally reduces foot blood flow. In postpubertal children with insulin-dependent diabetes, this postural vasoconstriction is impaired, indicating early microcirculation dysfunction even without complications.

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The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control.

Cardiovascular diabetology·2017

Area of Science:

  • Physiology
  • Endocrinology
  • Vascular Biology

Background:

  • Insulin-dependent diabetes can cause microcirculatory abnormalities.
  • These functional changes may precede clinical signs of microangiopathy.
  • Postural changes in blood flow regulation are crucial for maintaining tissue perfusion.

Purpose of the Study:

  • To investigate postural blood flow changes in the foot skin of diabetic children.
  • To compare prepubertal and postpubertal diabetic children with healthy controls.
  • To identify early microcirculatory dysfunction in pediatric diabetes.

Main Methods:

  • Laser Doppler fluximetry used to measure blood flow in the great toe pulp.
  • Assessed postural vasoconstriction by comparing dependent and supine blood flow.

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  • Compared measurements between diabetic and non-diabetic children across different pubertal stages.

    • Main Results:

    • Normal subjects showed greater postural vasoconstriction after puberty.
    • Prepubertal diabetic children's vasoconstriction did not differ from controls.
    • Postpubertal diabetic children exhibited significantly impaired postural vasoconstriction compared to controls.

    Conclusions:

    • Impaired postural vasoconstriction is evident in postpubertal children with insulin-dependent diabetes.
    • This microcirculatory abnormality can occur early in the disease, even in the absence of complications.
    • Findings highlight the importance of assessing microvascular function in pediatric diabetes management.