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Related Experiment Videos

Large-scale, population-based prospective studies in Japan

S Watanabe1

  • 1National Cancer Center Research Institute, Tokyo, Japan.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1993
PubMed
Summary
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This study establishes the Koseisho cohort, a large population-based prospective study in Japan, to investigate chronic disease risk factors and prevention strategies using detailed exposure assessments and biomarkers.

Area of Science:

  • Epidemiology
  • Public Health
  • Biomedical Research

Background:

  • Population-based prospective studies are crucial for understanding cancer risk factors.
  • Japan's "Koseki" registration system facilitates cohort follow-up.
  • Evolving lifestyles necessitate new studies with detailed exposure assessments.

Purpose of the Study:

  • Establish the "Koseisho" cohort for new population-based prospective research.
  • Investigate risk factors for chronic diseases, including cancer and cardiovascular diseases.
  • Integrate diverse health information sources for disease prevention.

Main Methods:

  • Established the Koseisho cohort (approx. 170,000 individuals) from 1990-1992.
  • Utilized biomarkers and linked data with mass screening registries.

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  • Collected and stored biological samples (sera, buffy coats) for future analysis.
  • Established disease registration committees for cancer and cardiovascular diseases.

    • Main Results:

    • The Koseisho cohort provides a valuable resource for studying chronic diseases.
    • Detailed exposure data and biomarkers are collected for a large population.
    • Ongoing data linkage and sample storage ensure long-term research potential.

    Conclusions:

    • The Koseisho cohort is a significant advancement in population-based prospective research in Japan.
    • This study will contribute to understanding and preventing chronic diseases.
    • Future research will focus on nutritional practices and other exposures.