Effect of fluconazole on neuromuscular transmission

The effect of the anti-fungal agent fluconazole on neuromuscular transmission was evaluated in vivo using the rat sciatic nerve-anterior tibialis muscle preparation. Fluconazole, 20 mg/kg, administered orally one hour before the experiment failed to alter the infusion rate of succinylcholine required to maintain 50% neuromuscular paralysis. In addition, the rate of recovery from succinylcholine induced paralysis or the final recovery of the muscle twitch response did not differ between control and fluconazole treated rats. Fluconazole alone at 20 or 40 mg/kg I.V. also failed to produce any observable effect in neuromuscular function. Acute fluconazole, therefore, at human therapeutic concentrations, fails to alter neuromuscular transmission in vivo in rats.