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Alterations in correlated activity parallel ICMS-induced representational plasticity

H R Dinse¹, G H Recanzone, M M Merzenich

¹Institut für Neuroinformatik, Ruhr-University Bochum, Germany.

|November 18, 1993

Summary

Neural interactions and correlated activity expand during representational plasticity. This suggests that synchronized neural firing is vital for forming functional neural groups and driving brain plasticity.

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Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Neural interactions, specifically correlated spontaneous activity, are fundamental to brain function.
Representational plasticity, the ability of neural representations to change, is a key mechanism for learning and adaptation.
Understanding the relationship between neural interactions and plasticity is crucial for deciphering brain mechanisms.

Purpose of the Study:

To investigate neural interactions using cross-correlation analysis during representational plasticity.
To determine the relationship between correlated spontaneous activity and receptive field overlap in cortical neurons.
To explore the role of neural cooperative processes in cortical reorganization induced by intracortical microstimulation (ICMS).

Main Methods:

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Simultaneous recording of neuron pairs in area 3b (monkeys) and cortical field SI (rats).
Cross-correlation analysis to quantify neural interactions and correlated spontaneous activity.
Intracortical microstimulation (ICMS) to induce representational plasticity.
Cortical mapping experiments to identify reorganized cortical sectors.

Main Results:

In normal animals, correlated activity extent correlated with receptive field overlap.
Following ICMS, the spatial extent of correlated activity significantly increased (several-fold).
Increased correlated activity was confined to the representationally reorganized cortical sector.

Conclusions:

Cortical reorganization and cooperative neural processes are closely linked.
Discharge coincidence is critical for the formation of functionally coupled neural groups.
Dynamically maintained neural groups play a role in postontogenetic plasticity.