Related Experiment Video
Updated: Sep 11, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
Analysis of genotype and phenotype on the same interphase or mitotic cell. A manual of MAC (morphology antibody
S Knuutila1, S J Nylund, M Wessman
1Department of Medical Genetics, University of Helsinki, Finland.
Abstract:
The purpose of this paper is to serve as a MAC (Morphology Antibody Chromosome) manual describing combined methodologies that allow simultaneous and/or sequential analysis of cell morphology, immunophenotype, and banded chromosomes and/or in situ hybridization signals. The MAC techniques used at the Department of Medical Genetics of the University of Helsinki, Finland, are described and modifications or related techniques reported by other authors are discussed. A list of references concerning applications is also given.
Related Concept Videos
Karyotyping
Meiosis vs. Mitosis
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

