Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patch testing in cutaneous reactions caused by carbamazepine

K Alanko1

  • 1Department of Dermatology, Helsinki University Central Hospital, Finland.

Contact Dermatitis
|November 1, 1993
PubMed
Summary

Patch testing can help diagnose carbamazepine allergy in patients experiencing maculopapular eruptions or exfoliative dermatitis. This method is useful for identifying carbamazepine-induced skin reactions when other diagnostic methods are inconclusive.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Time Trends in Adolescent School Absences and Associated Bullying Involvement Between 2000 and 2019: A Nationwide Study.

Child psychiatry and human development·2023
Same author

Time Trends in Adolescent School Absences and Associated Bullying Involvement Between 2000 and 2019: A Nationwide Study.

Child psychiatry and human development·2023
Same author

Long-term follow-up study of occupational hand eczema.

The British journal of dermatology·2010
Same author

Occupational contact allergy to formaldehyde and formaldehyde releasers.

Contact dermatitis·2008
Same author

Comparison of a Multidose Powder Inhaler Containing Beclomethasone Dipropionate (BDP) with a BDP Metered Dose Inhaler with Spacer in the Treatment of Asthmatic Patients.

Clinical drug investigation·2008
Same author

Correlated genetic and non-shared environmental influences account for the co-morbidity between female sexual dysfunctions.

Psychological medicine·2008

Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Carbamazepine is a common antiepileptic drug associated with various allergic skin reactions.
  • Accurate diagnosis of carbamazepine hypersensitivity is crucial for patient management and preventing severe adverse events.

Purpose of the Study:

  • To evaluate the diagnostic utility of patch testing for carbamazepine-induced allergic skin eruptions.
  • To correlate patch test results with specific clinical presentations of carbamazepine allergy.

Main Methods:

  • The study included 18 patients with a history of carbamazepine-induced skin eruptions.
  • Carbamazepine's etiological role was confirmed via provocation tests in 15 patients.
  • Patch testing with carbamazepine was performed, and reactions were analyzed based on clinical diagnosis.

Related Experiment Videos

Main Results:

  • Patch testing yielded positive results in 7 patients and doubtful reactions in 2.
  • Positive patch tests were observed exclusively in patients with exfoliative dermatitis (3/3) and maculopapular exanthema (4/7).
  • Patients with fixed drug eruption, erythema multiforme, or urticaria showed no positive patch test reactions.

Conclusions:

  • Patch testing demonstrates diagnostic value for carbamazepine allergy, particularly in cases of maculopapular eruptions and exfoliative dermatitis.
  • The findings suggest patch testing is a beneficial tool for identifying carbamazepine hypersensitivity in specific dermatological contexts.