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Related Experiment Videos

Experimental models of complete heart block

E K Weir, I F McMurtry, R F Grover

    Basic Research in Cardiology
    |July 1, 1975
    PubMed
    Summary

    Creating experimental complete heart block involves surgical or chemical methods. Pigs require prophylactic pacing to prevent fatal Stokes-Adams attacks when inducing heart block.

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    Area of Science:

    • Cardiovascular Research
    • Animal Models
    • Electrophysiology

    Background:

    • Review of historical and current methods for inducing experimental complete heart block since 1883.
    • Identification of three primary techniques: surgical ligation, chemical injection via thoracotomy, and transvenous catheter chemical injection.

    Purpose of the Study:

    • To comprehensively review methods for creating experimental complete heart block.
    • To discuss species-specific results, complications, and procedural variations.
    • To evaluate the suitability of pigs as a model for heart block research.

    Main Methods:

    • Detailed review of established techniques for inducing atrioventricular (A-V) bundle block.
    • Experimental induction of complete heart block in sixteen pigs.
    • Observation of mortality and complications, specifically Stokes-Adams attacks.

    Main Results:

    • Surgical ligation and chemical injection (via thoracotomy or transvenous catheter) are the most common methods.
    • Eleven out of sixteen pigs died from Stokes-Adams attacks after induced heart block.
    • Pigs have not been previously utilized as a model for experimental heart block.

    Conclusions:

    • Prophylactic pacing is essential when using pigs to model experimental heart block.
    • The study highlights the critical need for supportive care in this animal model.
    • Further research may benefit from understanding the high mortality rate in pigs with induced heart block.

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