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Related Experiment Videos

Decreased polymorphonuclear leukocyte deformability in NIDDM

Z Pécsvarády1, T C Fisher, C H Darwin

  • 1Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033.

Diabetes Care
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Polymorphonuclear leukocytes (PMN) from patients with non-insulin-dependent diabetes mellitus (NIDDM) exhibit increased rigidity. This heightened PMN rigidity may contribute to microcirculatory disturbances and microangiopathy in diabetic patients.

Area of Science:

  • Rheology
  • Diabetology
  • Cellular Biology

Background:

  • Non-insulin-dependent diabetes mellitus (NIDDM) is associated with microvascular complications.
  • Polymorphonuclear leukocytes (PMN) play a role in inflammatory and microcirculatory processes.

Purpose of the Study:

  • To investigate the rheological properties, specifically the deformability, of PMN in patients with NIDDM.
  • To compare PMN deformability in NIDDM patients with those having impaired glucose tolerance (IGT) and normal glucose tolerance (NGT).

Main Methods:

  • Utilized a Cell Transit Analyzer to measure PMN transit time through 8-micron pores.
  • Assessed PMN deformability under basal conditions, after cytochalasin B incubation, and following fMLP activation.
  • Included 33 NIDDM subjects, 13 IGT subjects, and 22 NGT subjects in the study.

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Main Results:

  • PMN from NIDDM patients demonstrated increased rigidity (longer transit time) compared to NGT and IGT groups under basal and cytochalasin B conditions.
  • PMN deformability was not significantly different between IGT and NGT groups.
  • Basal PMN transit time correlated with age, blood pressure, HbA1c, and serum lipid and creatinine levels. Hypertensive diabetic patients had less deformable PMN.

Conclusions:

  • PMN in NIDDM patients exhibit increased rigidity.
  • This altered rheological property of PMN may be a contributing factor to the development of microcirculatory disturbances and microangiopathy in diabetes.