Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Upper gastrointestinal endoscopy. Gasometric changes]

A J Martínez Conde1, L A Bermudez Gomez, M M Khassale Mardelli

  • 1Servicio de Gastroenterología, Hospital Vargas de Caracas.

G.E.N
|July 1, 1993
PubMed
Summary

Upper gastrointestinal endoscopy (UGE) can cause hypoxemia, especially when patients receive midazolam sedation. Monitoring arterial blood gases during UGE is crucial for patient safety, particularly in sedated individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

[Hemochromatosis: frequent but few times diagnosed].

G.E.N·1995
Same journal

[Early gastric cancer in the remnant stomach. Case report].

G.E.N·1995
Same journal

[Gastrointestinal stromal sarcoma. Report of a case and review of the literature].

G.E.N·1995
Same journal

[Primary intestinal lymphangiectasia in children. Report of 3 cases].

G.E.N·1995
Same journal

[Von Recklinghausen disease and hepatic neurofibromatosis].

G.E.N·1995
Same journal

[Effectiveness and innocuousness of the association of calcium dobesilate, dexamethasone acetate and lidocaine versus prednisolone capronate with dibucaine clorohydrate in the treatment of hemorrhoids-].

G.E.N·1995

Area of Science:

  • Anesthesiology
  • Pulmonology
  • Gastroenterology

Background:

  • Upper gastrointestinal endoscopy (UGE) is a common procedure.
  • Sedation is often used during UGE to improve patient comfort.
  • Potential impacts of UGE and sedation on respiratory function are not fully understood in healthy individuals.

Purpose of the Study:

  • To evaluate changes in arterial blood gases during UGE.
  • To compare these changes in patients with and without midazolam sedation.
  • To assess respiratory effects in patients without cardiopulmonary disorders or smoking habits.

Main Methods:

  • A randomized trial involving 65 patients (16-59 years old) without cardiopulmonary issues or smoking habits.
  • Group I (n=40) underwent UGE without sedation; Group II (n=25) received i.v. midazolam (0.05 mg/kg) before UGE.

Related Experiment Videos

  • Arterial blood gases (PO2, PCO2, pH) and oxygen saturation were measured before, during, and after sedation (Group II).

    • Main Results:

    • Hypoxemia (decreased PO2 and oxygen saturation) occurred in 55% of non-sedated patients and 64% of sedated patients.
    • Sedated patients showed significantly greater decreases in PO2 (18.8 mmHg) and oxygen saturation (3.3%) compared to non-sedated patients (p < 0.001).
    • No significant changes in PCO2 or pH were observed; however, reduced chest expansion was noted in 70% of sedated patients.

    Conclusions:

    • Hypoxemia is a common occurrence during UGE, even in healthy, non-smoking adults.
    • Midazolam sedation exacerbates hypoxemia and may reduce respiratory excursion during UGE.
    • Arterial blood gas monitoring is recommended during UGE, particularly in sedated patients.