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[Pregnancy in Marfan's syndrome]
J Farhi1, R Orvieto, Z Ben-Rafael
1Dept. of Obstetrics and Gynecology, Golda Meir Medical Center, Petah Tikva.
Harefuah
|December 1, 1993
Summary
Marfan syndrome, a genetic connective tissue disorder, poses significant risks for pregnant women. These include offspring inheritance, reduced life expectancy, and serious cardiovascular complications during pregnancy.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Obstetrics
Background:
- Marfan syndrome is an inherited connective tissue disorder impacting skeletal, cardiovascular, and ocular systems.
- Genetic disorders require careful management, especially during pregnancy.
Observation:
- Women with Marfan syndrome face a 50% risk of passing the condition to their children.
- Pregnancy exacerbates cardiovascular risks, including aortic aneurysm and dissection.
- Affected women have a reduced life expectancy, impacting their role as parents.
Findings:
- Pregnancy in women with Marfan syndrome is high-risk due to genetic transmission and maternal cardiovascular complications.
- Cardiovascular complications are a major concern during pregnancy for affected individuals.
Implications:
- Genetic counseling is crucial for women with Marfan syndrome considering pregnancy.
- Multidisciplinary care involving cardiologists and obstetricians is essential for managing high-risk pregnancies.
- Further research is needed to improve outcomes for Marfan syndrome patients and their offspring.