Partial deficiency of thyroxine-binding globulin: an HLA study
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Published on: May 2, 2013
O Hníková1, E Ivasková, P Kracmar
1Clinic of Children and Adolescents, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
Abstract:
Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.
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