Related Experiment Videos
Precise localization on chromosome 12 of the ATF-1 gene by fluorescence in situ hybridization
C Desmaze1, J Zucman, O Delattre
1Laboratoire de Génétique des Tumeurs, INSERM CJF 9201, Institut Curie, Paris, France.
Human Genetics
|February 1, 1994
Abstract:
The ATF-1 gene encodes for a transcription factor normally regulated by cAMP (Hai et al. 1989, Yoshimura et al. 1990). Recently, it has been shown to be involved in the recurrent t(12;22) translocation observed in soft tissue malignant melanoma, in a fusion gene with the EWS gene (Zucman et al. 1993). We report here on its precise localization on chromosome 12 by fluorescence in situ hybridization.