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Treating periodontal diseases by blocking tissue-destructive enzymes
L M Golub1, M Wolff, S Roberts
1Department of Oral Biology and Pathology, School of Dental Medicine, SUNY at Stony Brook 11794-8700.
Journal of the American Dental Association (1939)
|February 1, 1994
Abstract:
A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.