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Visualization of damaged brain tissue after ischemic stroke with cobalt-55 positron emission tomography
H M Jansen1, J Pruim, A M vd Vliet
1Department of Biological Psychiatry, Neurology, PET-Research Center, University Hospital Groningen, The Netherlands.
Abstract
Unlabelled:
In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+.
Methods:
The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke.
Results:
PET showed uptake of 55Co2+ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI.
Conclusion:
Our preliminary results indicate that 55CoCl2 may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.