Histological response on skeletal muscle to ischemia

The response of skeletal muscle to ischemia or trauma is similar whatever the mechanism of injury. Muscle has much more inherent ability to regenerate than has been recognized in the past. The extent of muscle damage is proportional to the duration and severity of the ischemic process. Circulation to ischemis muscle must be re-established as soon as possible. Early decompression of the appropriate compartemnts is an essential part of this procedure. No attempt should be made to excise muscle of doubtful or unknown viability during the initial decompression operation.