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Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study
E J Benjamin1, D Levy, S M Vaziri
1Framingham Heart Study, MA 01701.
Insights
Men have a higher risk of atrial fibrillation (AF) than women. Cardiovascular disease risk factors like diabetes, hypertension, and heart failure significantly increase AF risk in both sexes.
Area of Science:
- Cardiology
- Epidemiology
- Public Health
Background:
- Atrial fibrillation (AF) is a common arrhythmia with significant morbidity and mortality.
- Identifying independent risk factors for AF is crucial for targeted prevention strategies.
Purpose of the Study:
- To determine the independent risk factors for developing atrial fibrillation (AF) in a large cohort.
- To investigate sex-specific differences in AF risk factors.
Main Methods:
- A prospective cohort study was conducted using data from the Framingham Heart Study.
- 2090 men and 2641 women (aged 55-94) without a history of AF were followed for up to 38 years.
- Sex-specific logistic regression models identified independent risk factors, including age, smoking, diabetes, hypertension, heart failure, and valve disease.
Main Results:
- Men had a 1.5 times greater risk of developing AF than women, even after adjusting for risk factors.
- Advancing age, diabetes, hypertension, congestive heart failure, and valve disease were significant independent risk factors for AF in both sexes.
- Myocardial infarction was a risk factor in men, while women were more likely to have valve disease as a risk factor for AF.
Conclusions:
- Cardiovascular disease risk factors, alongside intrinsic cardiac conditions like valve disease and heart failure, contribute to AF development.
- Modifying cardiovascular disease risk factors may reduce the incidence of atrial fibrillation.
Objective:
To determine the independent risk factors for atrial fibrillation.
Design:
Cohort study.
Setting:
The Framingham Heart Study.
Subjects:
A total of 2090 men and 2641 women members of the original cohort, free of a history of atrial fibrillation, between the ages of 55 and 94 years.
Main Outcome Measures:
Sex-specific multiple logistic regression models to identify independent risk factors for atrial fibrillation, including age, smoking, diabetes, electrocardiographic left ventricular hypertrophy, hypertension, myocardial infarction, congestive heart failure, and valve disease.
Results:
During up to 38 years of follow-up, 264 men and 298 women developed atrial fibrillation. After adjusting for age and other risk factors for atrial fibrillation, men had a 1.5 times greater risk of developing atrial fibrillation than women. In the full multivariable model, the odds ratio (OR) of atrial fibrillation for each decade of advancing age was 2.1 for men and 2.2 for women (P < .0001). In addition, after multivariable adjustment, diabetes (OR, 1.4 for men and 1.6 for women), hypertension (OR, 1.5 for men and 1.4 for women), congestive heart failure (OR, 4.5 for men and 5.9 for women), and valve disease (OR, 1.8 for men and 3.4 for women) were significantly associated with risk for atrial fibrillation in both sexes. Myocardial infarction (OR, 1.4) was significantly associated with the development of atrial fibrillation in men. Women were significantly more likely than men to have valvular heart disease as a risk factor for atrial fibrillation. The multivariable models were largely unchanged after eliminating subjects with valvular heart disease.
Conclusion:
In addition to intrinsic cardiac causes such as valve disease and congestive heart failure, risk factors for cardiovascular disease also predispose to atrial fibrillation. Modification of risk factors for cardiovascular disease may have the added benefit of diminishing the incidence of atrial fibrillation.