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Liquid ventilation of primates

J H Modell, H W Calderwood, B C Ruiz

    Chest
    |January 1, 1976
    PubMed
    Summary
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    Primates can be successfully ventilated with liquid fluorocarbons, showing no obvious adverse effects after recovery. However, fluorocarbon traces remain in tissues for at least three years.

    Area of Science:

    • Biomedical Engineering
    • Respiratory Physiology
    • Toxicology

    Background:

    • Liquid ventilation offers potential for respiratory support in critical care.
    • Fluorocarbons are oxygen-carrying liquids investigated for medical applications.

    Purpose of the Study:

    • To evaluate the safety and long-term effects of liquid ventilation in primates.
    • To assess the retention of fluorocarbons in primate tissues after ventilation.

    Main Methods:

    • Adult monkeys underwent liquid ventilation using perfluoro bis (1, 4-isopropoxy) butane (Caroxin-D).
    • Ventilation periods varied from 10 to 60 minutes on separate occasions.
    • Animals were monitored for physiological parameters and tissue retention of fluorocarbons post-mortem.

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    Main Results:

    • Arterial blood gas levels remained adequate for survival during and after liquid ventilation.
    • No clinical evidence of adverse effects was observed in the animals.
    • Fluorocarbon was retained in various tissues, with highest concentrations in lungs and lymph nodes, for at least three years.

    Conclusions:

    • Primates tolerate repeated liquid ventilation with fluorocarbons without apparent immediate harm.
    • Fluorocarbon compounds are retained in tissues long-term, necessitating further investigation into their chronic effects.