Related Experiment Videos
[Blood chemistry, hematology of patients with liver cirrhosis]
R Kakehashi1, S Watanabe, J Ikoma
1Third Department of Internal Medicine, Mie University School of Medicine.
Insights
Laboratory tests reveal significant abnormalities in liver cirrhosis patients, with elevated liver enzymes and decreased blood counts. These findings are crucial for monitoring disease progression and guiding patient management.
Area of Science:
- Hepatology
- Clinical Biochemistry
- Diagnostic Medicine
Context:
- Liver cirrhosis presents with diverse laboratory abnormalities.
- Understanding these markers is key to assessing disease severity and type.
Purpose:
- To elucidate the spectrum of laboratory test abnormalities in liver cirrhosis.
- To correlate these findings with disease etiology and patient demographics.
Summary:
- Elevated serum glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and lactate dehydrogenase (LDH) indicate liver cell necrosis.
- Indocyanine green (ICG) test values reflect reduced hepatic blood flow and increased intrahepatic shunting.
- Hypersplenism leads to decreased white blood cell and platelet counts.
- Alcoholic liver cirrhosis shows more pronounced reductions in serum albumin and cholineesterase compared to viral causes.
- Age influences liver enzyme levels, with lower elevations in older patients.
Impact:
- Highlights the diagnostic and prognostic value of routine laboratory tests in liver cirrhosis.
- Emphasizes the importance of serial monitoring for effective patient management.
- Provides insights into differentiating between alcoholic and viral etiologies based on specific biomarkers.
Abstract:
In patients with liver cirrhosis, there were many abnormalities in laboratory tests. Serum GOT, GPT and LDH were elevated due to the liver cell necrosis. The value of ICG tests reflected the decrease of effective hepatic blood flow and the increase of intrahepatic shunt flow. White blood cell counts and the number of platelet were decreased due to the hypersplenism. Serum albumin and cholineesterase levels were decreased more remarkably in patients with alcoholic liver cirrhosis than in patients with viral liver cirrhosis. Raised GOT and GPT levels were lower in aged patients than in young patients. Serial laboratory tests were important for the management of patients with liver cirrhosis.