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[Deep venous thrombosis associated with necrotizing vasculitis]

F Cofán1, A Serra, J Teixidó

  • 1Servicio de Nefrología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona.

Medicina Clinica
|December 11, 1993
PubMed
Summary

Deep vein thrombosis (DVT) is rarely linked to systemic necrotizing vasculitis. This study analyzes cases, highlighting advanced age and thrombocytosis as risk factors for DVT in vasculitis patients.

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Area of Science:

  • Rheumatology
  • Hematology
  • Internal Medicine

Background:

  • Systemic necrotizing vasculitis is a group of rare autoimmune diseases.
  • Deep vein thrombosis (DVT) is a condition involving blood clots in deep veins, often in the legs.
  • The association between DVT and systemic necrotizing vasculitis is infrequent.

Observation:

  • This report details two patients with microscopic polyarteritis and one with overlap syndrome who developed DVT.
  • In two patients, DVT occurred simultaneously with vasculitis diagnosis.
  • One patient's DVT was the primary reason for hospitalization.

Findings:

  • Advanced age and thrombocytosis were identified as factors associated with vasculitis that may predispose patients to thromboembolic disease.
  • Pulmonary embolism complicated DVT in two of the described cases.

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  • Antiphospholipid syndrome was ruled out in these patients.

    • Implications:

    • Despite its rarity, the association between DVT and systemic necrotizing vasculitis warrants clinical consideration.
    • Recognizing this link is crucial for managing potential severe complications, including pulmonary embolism.
    • Further research into the pathogenic mechanisms of this infrequent association is needed.