Role of endothelial cells in cardiovascular function

Since the first description of vascular endothelium-dependent relaxation in response to acetylcholine, the role of endothelial cells in the regulation of cardiovascular function has been increasingly studied. The identification of endothelial releasing factors such as nitric oxide and endothelin has enabled us to better understand the mechanisms involved in autoregulation. It has also been shown that both vascular and endocardial endothelium can modify the contractile characteristics of their adjacent myocardium. In the heart, these modulating effects of endothelial cells are more widespread than previously thought and, can be the result of the direct effects of endocardial and vascular endothelial cells and their indirect effects, via modulation of the myocardial response to inotropic agents.