[Antimutagenic effect of culture fluid obtained as a result of propionic acid fermentation]

It was shown for first time that propionic acid bacteria excrete in the medium substances with antimutagenic activity against mutagenicity of 4-nitroquinoline-N-oxide in Salmonella typhimurium TA100. The substances act as antimutagens. Antimutagenic action of filtrate of culture liquid increased with time preincubation with mutagen and dose increase. The most activity was found in the culture of logarithmic and early stationary phase (24-48 h). The substances with antimutagenic activity are formed in the medium with glucose, lactose and lactate. Antimutagenic factor (factors) is dialysable, thermostable and is not presented with peptide.