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Cerebrospinal fluid-intracranial volume ratio measurements in patients with HIV infection: CLASS image analysis
M N Paley1, W K Chong, I D Wilkinson
1Department of Neurology, University College London Medical School and Middlesex Hospital, England.
Purpose:
To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.
Materials And Methods:
A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.
Results:
The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).
Conclusion:
No substantial change in CSF/ICV occurs until development of late-stage AIDS.