Related Experiment Video

Updated: Aug 19, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Cromolyn sodium in the treatment of children with asthma

M Rao, P Steiner, M Victoria

    The Journal of Asthma Research
    |March 1, 1975
    PubMed

    Insights

    Cromolyn sodium effectively managed chronic asthma in 80% of children, significantly reducing or eliminating the need for steroid medications. This asthma treatment offers a promising alternative for pediatric patients.

    Area of Science:

    • Pediatric Pulmonology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Chronic asthma in children presents significant management challenges.
    • Steroid dependence is a common concern in pediatric asthma care.
    • Alternative therapeutic options are continuously sought for long-term asthma control.

    Purpose of the Study:

    • To evaluate the efficacy of cromolyn sodium in managing chronic, intractable asthma in pediatric patients.
    • To assess the impact of cromolyn sodium on steroid requirements in children with asthma.

    Main Methods:

    • A cohort of fifteen children with chronic, intractable asthma was treated with cromolyn sodium.
    • Patient outcomes and steroid dosages were monitored throughout the treatment period.

    Main Results:

    • Overall improvement was observed in 80% of the pediatric patients treated with cromolyn sodium.
    • A significant reduction or complete elimination of steroid requirement was noted in a substantial proportion of patients.
    • Cromolyn sodium demonstrated a favorable safety profile in this pediatric cohort.

    Conclusions:

    • Cromolyn sodium is an effective therapeutic agent for managing chronic, intractable asthma in children.
    • The drug shows potential in reducing or eliminating the need for corticosteroid therapy, thereby mitigating associated side effects.
    • Further research into long-term efficacy and broader application in pediatric asthma management is warranted.

    More Related Videos

    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System07:28

    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

    Published on: April 6, 2017

    A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion05:56

    A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

    Published on: May 12, 2023

    Related Concept Videos

    Asthma: Pathogenesis and Management01:20

    Asthma: Pathogenesis and Management

    Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
    Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
    Antiasthma Drugs: Methylxanthines01:24

    Antiasthma Drugs: Methylxanthines

    Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
    Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
    Antiasthma Drugs: Leukotriene Modifiers01:19

    Antiasthma Drugs: Leukotriene Modifiers

    Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
    Leukotriene modifiers work through two distinct mechanisms:
    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

    Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
    ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

    Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
    Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
    Asthma-IV: Diagnostic and Management01:30

    Asthma-IV: Diagnostic and Management

    The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
    Clinical Assessment for Asthma:
    This is the first step in diagnosing and managing asthma. It includes: