The migration of astrocytes after implantation to immature brains

Using a species-specific marker, we have found that astrocytes, taken from donors of varying ages from fetal to adult, migrate in highly stereotypic patterns in immature host brains. Migration is primarily within and towards cell layers, although some cells are seen to migrate along fibre bundles. This contrasts with studies using the same approach in mature hosts, where migration is predominantly within fibre layers, largely excluding cellular regions.