Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Survival in trisomy 18

S Root1, J C Carey

  • 1Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84112.

American Journal of Medical Genetics
|January 15, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature and Density on the Forsterite Liquid-Vapor Phase Boundary.

Journal of geophysical research. Planets·2021
Same author

Anthropocene survival of southern New England's salt marshes.

Estuaries and coasts : journal of the Estuarine Research Federation·2018
Same author

Contrasting decadal-scale changes in elevation and vegetation in two Long Island Sound salt marshes.

Estuaries and coasts : journal of the Estuarine Research Federation·2018
Same author

Author Correction: Crowther et al. reply.

Nature·2018
Same author

Crowther et al. reply.

Nature·2018
Same author

Quantifying global soil carbon losses in response to warming.

Nature·2016

Trisomy 18 (Edwards syndrome) survival rates are shorter than previously reported, with a median survival of 4 days. However, Utah data shows higher 6-month and 1-year survival compared to recent studies.

Area of Science:

  • Genetics
  • Pediatrics
  • Prenatal Diagnosis

Background:

  • Prenatal diagnosis of trisomy 18 is common, necessitating accurate prognostic information for families.
  • Recent studies indicate significantly shorter survival for trisomy 18 than previously documented.
  • Understanding current survival trends is vital for informed decision-making regarding delivery management.

Purpose of the Study:

  • To investigate trisomy 18 survival rates.
  • To compare current survival data with historical and recent findings.
  • To provide updated prognostic information for trisomy 18.

Main Methods:

  • Analysis of chromosome laboratory records for trisomy 18 diagnoses in Utah (1979-1988).
  • Utilized death certificates and hospital records to determine survival outcomes.

Related Experiment Videos

  • Calculated prevalence, median survival, and survival rates at 1 week, 6 months, and 1 year.

    • Main Results:

    • Identified 64 liveborn cases of trisomy 18, with a prevalence of 1/6071.
    • Median survival was 4 days; 45% survived 1 week, aligning with recent studies.
    • Utah data showed higher survival at 6 months (9%) and 1 year (5%) compared to other recent studies (3% and 0%, respectively).

    Conclusions:

    • Trisomy 18 survival appears shorter than in earlier reports, likely influenced by earlier diagnosis.
    • While short-term survival aligns with recent data, Utah's long-term survival rates at 6 months and 1 year are notably higher.
    • Discrepancies in long-term survival may be attributed to variations in diagnostic timing and potentially small study numbers.