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Related Experiment Videos

Needle localization for nonpalpable breast lesions

D M Sailors1, J D Crabtree, R L Land

  • 1Department of Surgery, University of Tennessee College of Medicine, Erlanger Medical Center, Chattanooga 37403.

The American Surgeon
|March 1, 1994
PubMed
Summary

Early breast cancer detection through mammography is crucial. Needle localization biopsies identified malignancy in 17% of cases, with calcifications and upper outer quadrant masses indicating higher risks.

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Area of Science:

  • Oncology
  • Radiology
  • Surgical Pathology

Background:

  • Breast cancer affects approximately 1 in 9 women, with early detection being key due to lack of prevention methods.
  • Mammography significantly improves early breast cancer detection by identifying nonpalpable lesions.
  • Screening mammography and regular breast examinations are emphasized for early breast cancer diagnosis.

Purpose of the Study:

  • To evaluate the efficacy of needle localization breast biopsies in detecting malignancy.
  • To analyze mammographic findings and their correlation with malignancy rates.
  • To determine the incidence of malignancy based on lesion characteristics and location.

Main Methods:

  • A retrospective review of 1,323 breast biopsies performed between January 1987 and January 1992.

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  • Focus on 559 needle localization biopsies from 541 patients.
  • Analysis of mammographic abnormalities, biopsy results, patient age, lesion location, and treatment outcomes.

    • Main Results:

    • Out of 559 needle localization biopsies, 92 (17%) were positive for malignancy.
    • The mean age of patients with malignant lesions was 55.2 years.
    • Irregular breast tissue matrix was the most common mammographic abnormality (13% malignancy rate).
    • Calcifications with a mass or density showed the highest malignancy rate (29%).
    • The upper outer quadrant (UOQ) was the most common biopsy site (56%) and had the highest malignancy incidence (21%).
    • Microscopic invasion correlated with node-negative status, unlike tumor size.
    • Preinvasive (in-situ) lesions were found in 25% of malignant biopsies, with no axillary involvement.

    Conclusions:

    • Needle localization biopsy is an effective tool for diagnosing breast cancer, particularly for nonpalpable lesions identified by mammography.
    • Specific mammographic findings, such as calcifications with a mass and lesions in the UOQ, are associated with higher malignancy rates.
    • Early detection and accurate diagnosis through mammography and biopsy are critical for appropriate surgical management and patient outcomes.