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A mouse TGF-beta type I receptor that requires type II receptor for ligand binding
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Biochemical and Biophysical Research Communications
|February 15, 1994
Abstract:
A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.