Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small bowel transplantation: an overview

R W de Bruin1, E Heineman, R L Marquet

  • 1Department of General Surgery, Erasmus University, Rotterdam, The Netherlands.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What is the long-term clinical outcome after fragility fractures of the pelvis? - A CT-based cross-sectional study.

Injury·2021
Same author

Minimal important change in physical function in trauma patients: a study using the short musculoskeletal function assessment.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2020
Same author

Long-term physical functioning and quality of life after pelvic ring injuries.

Archives of orthopaedic and trauma surgery·2019
Same author

Short Musculoskeletal Function Assessment: normative data of the Dutch population.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2015
Same author

The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial.

Alcohol (Fayetteville, N.Y.)·2015
Same author

The effect of a preoperative warm-up with a custom-made Nintendo video game on the performance of laparoscopic surgeons.

Surgical endoscopy·2014
Same journal

Cold ischemia time exceeding 12 hours is a risk factor for delayed graft function and increased mortality in kidney transplant recipients within the eurotransplant senior program.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Impact of pre-transplantation exposure to immunosuppressive agents on lung transplant outcomes in interstitial lung disease.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Regulatory approach to manipulated organs in Europe: preserving human organs as non-commercial goods.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Can european law keep pace with biomedical innovation? The reinvention of transplantation regulation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Sex-related differences in survival based on [<sup>18</sup>F]FDG PET/CT metabolic tumor volume after liver transplantation for colorectal liver metastases.

Transplant international : official journal of the European Society for Organ Transplantation·2026
See all related articles

Small bowel transplantation (SBT) offers theoretical promise for short bowel syndrome. However, challenges like graft rejection and graft-versus-host disease (GVHD) hinder its widespread application, despite ongoing research.

Area of Science:

  • Gastroenterology
  • Transplantation Immunology

Background:

  • Short bowel syndrome (SBS) necessitates alternative treatments like small bowel transplantation (SBT).
  • SBT is theoretically ideal for SBS patients reliant on total parenteral nutrition (TPN).

Purpose of the Study:

  • To outline the history, recent advancements, and future prospects of small bowel transplantation.
  • To discuss the challenges and potential of SBT as a treatment for short bowel syndrome.

Main Methods:

  • Review of historical data on small bowel transplantation.
  • Analysis of recent experimental and clinical studies in SBT.
  • Discussion of immunological challenges including rejection and GVHD.

Main Results:

Related Experiment Videos

  • Small bowel transplantation faces significant immunological hurdles, including rejection and graft-versus-host disease (GVHD).
  • Graft rejection can lead to graft dysfunction and bacterial translocation, increasing sepsis risk.
  • Immunosuppression required to prevent rejection exacerbates the risk of fatal sepsis.

    • Conclusions:

    • Small bowel transplantation, while theoretically optimal for short bowel syndrome, is not yet a widely applicable therapy.
    • Overcoming immunological challenges is crucial for the successful clinical implementation of SBT.
    • Further research into experimental and clinical SBT is needed to improve outcomes for TPN-dependent patients.