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[The tissue renin-angiotensin systems]

G G Neri Serneri1, M Boddi, M Coppo

  • 1Center for Heart and Thrombosis Research, Università degli Studi di Firenze.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|October 1, 1993
PubMed
Summary

The local tissue renin-angiotensin system operates independently from the plasma system. Inhibiting only the plasma renin-angiotensin system may not be therapeutically sufficient.

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Area of Science:

  • Physiology
  • Biochemistry

Context:

  • Recent advances in cell biology and molecular techniques have reshaped the understanding of the renin-angiotensin system.
  • Evidence suggests the existence of tissue-based renin-angiotensin systems in cardiac, cerebral, renal, vascular, and gonadal tissues.

Purpose:

  • To review the evolving understanding of the renin-angiotensin system.
  • To highlight the discovery and implications of local, tissue-based renin-angiotensin systems.

Summary:

  • The renin-angiotensin system is now understood to exist as local, tissue-based systems independent of the plasma system.
  • These local systems produce angiotensins I and II, influencing their plasma counterparts while functioning autonomously with unique regulatory mechanisms.
  • This multicentric organization impacts both physiological and pathophysiological processes.

Impact:

  • The discovery of independent local renin-angiotensin systems has significant therapeutic implications.
  • Inhibiting only the plasma renin-angiotensin system may be insufficient for effective treatment.
  • Future therapeutic strategies may need to consider targeting these local tissue-based systems.

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