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Clozapine cases with fatal, toxic or therapeutic concentrations
K Worm1, B Kringsholm, A Steentoft
1Institute of Forensic Chemistry, University of Copenhagen, Denmark.
International Journal of Legal Medicine
|January 1, 1993
Abstract:
The neuroleptic drug clozapine is used in the treatment of schizophrenia and is characterized by not having the extrapyramidal side-effects usually shown by neuroleptics. Unfortunately clozapine has other side-effects, which limit its use. This study presents methods for the analysis of clozapine and desmethylclozapine in whole blood and tissue. Case histories and pathology findings are described for 3 autopsy cases with fatal concentrations of clozapine, 5 with toxic concentrations and 2 with therapeutic concentrations together with the concentrations found in a living person.